> AlphaFold would have to be able to synthesize arbitrary proteins and run the experiments on them to verify and correct its predictions.
Could this lead to a virtuous cycle where AlphaFold is used generate a ton of random sequences where it has low confidence, those are then screened for ease of synthesis, measured and the results used to improve the model?
Edit: nevermind, according to another comment[0] there are still plenty of real proteins without experimental data left to explore.
Could this lead to a virtuous cycle where AlphaFold is used generate a ton of random sequences where it has low confidence, those are then screened for ease of synthesis, measured and the results used to improve the model?
Edit: nevermind, according to another comment[0] there are still plenty of real proteins without experimental data left to explore.
[0] https://news.ycombinator.com/item?id=25255601