I like reStructuredText, but the format is grating compared to markdown. The two things I do the most are sectioning and links. Inline links are ok in rst, but I prefer markdown. Sectioning though is awful. I hate having to hold the damn == or -- or ~~ down and getting the length right. It's easier to parse when you read the plaintext, but makes me loath writing it. Most the time I deal with md or rst, they end up formatted anyway, which is the point IMO.

Personally I don't think sectioning is that bad, a little annoying when working with other people that don't do it, though...

   foo
   ======================

... the easy and built-in extensibility is a huge plus though, as is Sphinx and the pretty good output writers for many formats. Sphinx btw. works with Markdown, too.

Quite possibly my biggest annoyance with rST/Sphinx is the hanging toctree issue, and poor support for multi-format images/figures.

The 100 % offline search in Sphinx is somewhat of a mixed bag and doesn't always give good results, though it's fine for reference works.